Methods of determining polypeptide structure and function

Details Methods of determining polypeptide structure and function Methods of determining polypeptide structure and function

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C12P 21/00 (2006.01) C12Q 1/48 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2388268

The present invention provides methods for determining the structure and/or function of one or more domains of a cation-dependent (and preferably calcium-dependent) polypeptide (particularly a calcium-dependent enzyme, which may be a protease such as calpain) in the presence of one or more cations. The invention further provides methods for identifying a ligand having the ability to bind to one or more ligand-binding domains (LBDs) of a cation-dependent (and preferably calcium-dependent) polypeptide, and ligands identified by these methods. The invention also provides methods of treating or preventing physical disorders in animals using these ligands.

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