Methods of determining precise herg interactions and...

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G01N 33/566 (2006.01) C07K 1/107 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2486193

The present invention discloses methods of determining highly precise interactions between the HERG ion channel and various compounds. The methods of the present invention utilize the nonsense codon suppression methods combined with heterologous in vivo expression in Xenopus oocytes.

L'invention concerne des méthodes permettant de déterminer des interactions extrêmement précises entre le canal ionique HERG et divers composés. Les méthodes selon l'invention utilisent les méthodes de suppression des codons non-sens combinées avec l'expression in vivo hétérologue dans les oocytes Xenopus.

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