Methods of determining the concentration of an analyte in a...

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G01N 27/26 (2006.01) C12Q 1/00 (2006.01) G01N 27/48 (2006.01) G01N 33/487 (2006.01) G01N 33/49 (2006.01) G01N 33/50 (2006.01) G01N 33/66 (2006.01) G01N 27/49 (2006.01)

Patent

CA 2457500

A method of determining the concentration of an analyte in a fluid test sample that in- cludes providing an electrochemical sensor adapted to measure the analyte in the test sample. The test sample sufficiently covers a counter and working electrode of the electrochemical sensor. A first potential is applied between the counter and working electrodes for a first pre- determined time period and the current is measured and the time is recorded. After the first potential is removed or substantially reduced, a second potential is applied between the counter and working electrodes and the current is measured. The concentration of the analyte is determined in the test sample as a function of the current measured. An index is calculated and compared to at least one predetermined parameter to identify when a bias, if any, exceeds a threshold. An error signal or analyte concentration is displayed depending on the compari- son.

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