Methods of developing a stem cell line

Details Methods of developing a stem cell line Methods of developing a stem cell line

C - Chemistry, Metallurgy

12

N

C12N 5/0735 (2010.01) C12N 5/073 (2010.01) C12Q 1/68 (2006.01)

Patent

CA 2585985

The invention relates to a methodology for creating an embryonic stem cell line. The stem cells derived from the invention are of substantially better quality of human stem cells currently known to exist. The inventors have discovered inter alia, that when the chromosome complement of a first polar body (PB-I) is normal, it alone is in more than 80% of cases sufficient to predict that an embryo which has developed from an oocyte associated with the PB-I is also euploid and competent. Euploid embryos ensure are a key prerequisite in the making of euploid embryonic stem cells. This allows the technician minimize the number of disrupted embryos by only disrupting those embryos determined to be euploid.

L'invention concerne une méthodologie permettant de créer une ligne de cellules souches embryonnaires. Les cellules souches dérivées sont de qualité sensiblement supérieure à celle des cellules souches humaines dont on connaît l'existence. L'invention concerne la découverte inter alia selon laquelle quand le complément chromosomique d'un premier corps polaire (PB-I) est normal, il est à lui seul, dans plus de 80 % de cas, suffisant pour prévoir qu'un embryon s'étant développé à partir d'un ovocyte associé au PB-I est également euploïde et compétent. Des embryons euploïdes sûrs représentent une condition préalable clef dans la fabrication de cellules souches embryonnaires euploïdes, permettant ainsi au technicien de minimiser le nombre d'embryons interrompus uniquement par interruption de ces embryons dont on a déterminé qu'ils sont euploïdes.

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