G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/48 (2006.01) A61B 5/00 (2006.01) A61K 31/16 (2006.01) A61K 33/24 (2006.01) A61K 38/02 (2006.01) A61P 39/04 (2006.01) G01N 33/68 (2006.01) G01N 33/74 (2006.01) G01N 33/90 (2006.01)
Patent
CA 2705495
The present invention relates to novel methods of treating or reducing the likelihood of developing gadolinium toxicity by administering to a patient a metal chelator before, concurrently with, or after exposure to gadolinium. The novel methods comprise, inter alia, the use of iron chelators to aid patients at increased risk of developing a gadolinium-induced condition, such as nephrogenic systemic fibrosis, acute kidney injury, cardiovascular disease and accelerated senescence.
La présente invention concerne des procédés inédits de traitement d'un empoisonnement au gadolinium ou de réduction de la probabilité d'apparition d'un empoisonnement au gadolinium par l'administration au patient d'un chélateur de métal avant, pendant ou après une exposition au gadolinium. Ces procédés inédits comprennent, entre autres, le recours à des chélateurs du fer pour prendre en charge des patients courant un risque accru de souffrir d'une affection provoquée par le gadolinium, par exemple de type fibrose systémique néphrogène, lésion rénale aiguë, maladie cardiovasculaire et sénescence accélérée.
Shah Sudhir V.
Sundararaman Swaminathan
Cormedix Inc.
Smart & Biggar
LandOfFree
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