C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2184780
The present invention relates generally to methods of diagnosing and treating cancer and more particularly colon cancer. Even more particularly, the present invention provides a genetically manipulated live animal model useful for developing diagnostic and treatment protocols for colon cancer. The present invention further provides agents useful for diagnosing and treating colon cancer in animals such as mammals including humans. In a particularly preferred embodiment the present invention provides a genetically altered animal or progeny of said animal wherein said animal comprises a mutation in at least one allele of Cdx2 or equivalent thereof and which is a homologue of the Drosophila caudal gene and wherein said genetically altered animal has a predisposition to develop growth of neoplastic cells in intestinal epithelium.
Beck Felix
Howard Florey Institute Of Experimental Physiology And Medicine
Smart & Biggar
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