Methods of diagnosing and treating multiple sclerosis

Details Methods of diagnosing and treating multiple sclerosis Methods of diagnosing and treating multiple sclerosis

G - Physics

01

N

G01N 33/92 (2006.01) C07J 9/00 (2006.01)

Patent

CA 2750100

Methods of using a 15-oxysterol, e.g., 15-ketocholestene (15-KE), 15- ketocholestane (15-KA), and/or 15-hydroxy-cholestene (15-HC), as a biomarker to monitor disease progression in multiple sclerosis (MS), and methods of treating secondary progressive MS (SPMS) using inhibitors of poly(ADP ribose) polymerase-1 (PARP- 1).

La présente invention concerne des méthodes d'utilisation d'un 15-oxystérol, par exemple le 15-cétocholestène (15-KE), le 15-cétocholestane (15-KA) et/ou le 15-hydroxycholestène (15-HC), en tant que biomarqueur en vue du suivi de la progression de la maladie dans le cas d'une sclérose en plaques (SEP), ainsi que des méthodes de traitement de la SEP secondairement progressive (SEP-SP) au moyen d'inhibiteurs de la poly(ADP-ribose)polymérase-1 (PARP-1).

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