Methods of diagnosing and treating pre-eclampsia or eclampsia

Details Methods of diagnosing and treating pre-eclampsia or eclampsia Methods of diagnosing and treating pre-eclampsia or eclampsia

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/18 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2554971

Disclosed herein are methods for treating pre-eclampsia or eclampsia using compounds that increase VEGF or P1GF levels or compounds that decrease sF1t-1 levels. Also disclosed here in are methods for monitoring the treatment of pre- eclampsia or eclampsia by detecting the levels of sF1t-1, VEGF, or P1GF. Also disclosed herein are methods for diagnosing pre-eclampsia and eclampsia by detecting the levels of sF1t-1, VEGF, and P1GF in a subject.

L'invention concerne des méthodes permettant de traiter la prééclampsie ou l'éclampsie au moyen de composés qui augmentent les taux de VEGF ou de PlGF ou de composés qui abaissent les taux de sFlt-1. L'invention concerne également des méthodes permettant de contrôler le traitement de la prééclampsie ou de l'éclampsie en mesurant les taux de sFlt-1, de VEGF, ou de PlGF. L'invention concerne en outre des méthodes permettant de diagnostiquer la prééclampsie et l'éclampsie par mesure des taux de sFlt-1, de VEGF, et de P1GF chez un sujet.

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