C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12Q 1/04 (2006.01) C12Q 1/06 (2006.01) G01N 33/48 (2006.01)
Patent
CA 2650706
The invention provides a novel cell that is a precursor of a fibroblast-like synovial cell. The novel cell is a circulating synovial tissue cell that stains positive for collagen, CD34, CD45, prolyl 4-hydroxylase and CD14. The invention also relates to methods of diagnosing or monitoring rheumatoid arthritis and/or osteoarthritis using gene expression profiles, protein expression profiles, and/or protein phosphorylation profiles of different cell types, including the novel precursor, CD3+ cells, synovial tissue fibroblast-like synovial cells and fibrocytes. The invention also includes methods to identify substances to treat or prevent rheumatoid arthritis and/or osteoarthritis.
La présente invention concerne une cellule précurseur d'une cellule synoviale ressemblant à un fibroblaste. Cette cellule est une cellule de tissu synovial circulant qui se colore en positif avec le collagène, CD34, CD45, la prolyle 4-hydroxylase et CD14. L'invention concerne également des procédés permettant de diagnostiquer ou de surveiller l'arthrite rhumatoïde et/ou l'arthrose au moyen de profils d'expression des gènes, profils d'expression de protéine, et/ou de profiles de phosphorylation de protéines de différents types de cellule, y-compris le nouveau précurseur de l'invention, les cellules CD3+, les cellule de tissu synovial ressemblant à un fibroblaste et les fibrocytes. L'invention concerne enfin des procédés permettant d'identifier des substances aptes à traiter ou prévenir l'arthrite rhumatoïde et/ou l'arthrose.
Bykerk Vivian
Fish Eleanor N.
Galligan Carole
Keystone Edward
Perez Omar
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Mount Sinai Hospital
The Board Of Trustees Of The Leland Stanford Junior University
University Health Network
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