C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/519 (2006.01) A61K 31/7105 (2006.01) A61K 31/713 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) C07H 21/04 (2006.01) C07K 14/71 (2006.01)
Patent
CA 2680046
Diagnostic and therapeutic applications for endometrial cancer are described. The diagnostic and therapeutic applications are based on certain activation mutations in the FGFR2 gene and its expression products. The present invention is directed to nucleotide sequences, amino acid sequences, probes, and primers related to FGFR2 activation mutants and kits comprising these mutants to diagnosis and classify endometrial cancer in a subject.
La présente invention concerne des applications diagnostiques et thérapeutiques pour le cancer de l'endomètre. Les applications diagnostiques et thérapeutiques sont basées sur certaines mutations d'activation dans le gène FGFR2 et ses produits d'expression. La présente invention concerne des séquences de nucléotides, des séquences d'acides aminés, des sondes, et des amorces associées à des mutants d'activation du FGFR2. Elle concerne également des kits comprenant ces mutants destinés à diagnostiquer et à classifier un cancer de l'endomètre chez un sujet.
Goodfellow Paul
Pollock Pamela
Borden Ladner Gervais Llp
The Translational Genomics Research Institute
Washington University
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