Methods of diagnosing liver fibrosis

Details Methods of diagnosing liver fibrosis Methods of diagnosing liver fibrosis

G - Physics

01

N

G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2476696

The present invention provides a method of diagnosing the presence or severity of liver fibrosis in an individual by detecting .alpha.2-macroglobulin (.alpha.2-MG) in sample from the individual; detecting hyaluronic acid (HA) in a sample from the individual; detecting tissue inhibitor of metalloproteinases- 1 (TIMP-1) in a sample from the individual; and diagnosing the presence or severity of liver fibrosis in the individual based on the presence or level of .alpha.-MG, HA and TIMP-1.

L'invention concerne un procédé permettant de diagnostiquer la présence ou la sévérité d'une fibrose hépatique chez un sujet par détection, dans un échantillon provenant du sujet, de la macroglobuline A2 (?2-MG), de l'acide hyaluronique (HA), d'inhibiteur tissulaire de métalloprotéinases-1 (TIMP-1), puis de diagnostiquer la présence ou la sévérité de fibrose hépatique chez ce sujet sur la base de la présence ou des niveaux d'?-MG, de HA et de TIMP-1.

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