Methods of diagnosing muscle damage

Details Methods of diagnosing muscle damage Methods of diagnosing muscle damage

G - Physics

01

N

G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/545 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01) C12Q 1/25 (2006.01) G01N 27/447 (2006.01) G01N 30/02 (2006.01)

Patent

CA 2659003

A method for assessing muscle damage in a biological sample obtained from a subject is disclosed. The method involves obtaining a biological sample from a subject being assessed for muscle damage, and evaluating the sample for the presence or absence of a myofilament protein modification product. The method can also be used to assess the extent and/or type of muscle damage in a subject by studying the profile of myofilament protein modification products detected in the sample taken from the subject. The invention further provides a method for screening for an agent which modulates the level of a myofilament protein modification product present in a biological sample or for a calcium sensitizing agent. The invention is applicable to cardiac muscle and skeletal muscle.

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