Methods of diagnosing or treating prostate cancer using the...

Details Methods of diagnosing or treating prostate cancer using the... Methods of diagnosing or treating prostate cancer using the...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2565450

The present invention relates to oncogenes or tumor suppressor genes, as well as other genes, involved in prostate cancer and their expression products, as well as derivatives and analogs thereof. Provided are therapeutic compositions and methods of detecting and treating cancer, including prostate and other related cancers. Also provided are methods of diagnosing and/or prognosing prostate cancer by determining the expression level of at least one prostate cancer-cell-specific gene, including, for example, the ERG gene or the LTF gene alone, or in combination with at least one of the AMACR gene and the DD3 gene.

L'invention concerne des oncogènes ou des gènes suppresseurs de tumeur ainsi que d'autres gènes, impliqués dans le cancer de la prostate, leurs produits d'expression ainsi que des dérivés ou des analogues de ceux-ci. Des compositions thérapeutiques et des méthodes de détection et de traitement du cancer, dont le cancer de la prostate et d'autres cancers apparentés, sont décrits. Par ailleurs,. des méthodes de diagnostic et/ou de pronostic du cancer de la prostate par la détermination du niveau d'expression d'au moins un gène spécifique des cellules du cancer de la prostate, dont, par exemple, le gène ERG ou le gène LTF seul ou combiné à au moins le gène AMACR et DD3, sont présentées.

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