C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 229/16 (2006.01) A61K 31/00 (2006.01) A61K 31/36 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) C07D 211/26 (2006.01) C07D 217/00 (2006.01) C07D 217/02 (2006.01) C07D 217/20 (2006.01) C07D 221/18 (2006.01) C07D 317/58 (2006.01) C07D 455/03 (2006.01) G01N 33/48 (2006.01)
Patent
CA 2719505
The present invention provides methods and therapeutic agents for lowering or increasing serum serotonin levels in a patient in order to increase or decrease bone mass, respectively. In preferred embodiments, the patient is known to have, or to be at risk for, a low bone mass disease such as osteoporosis and the agents are TPH1 inhibitors or serotonin receptor antagonists.
La présente invention concerne des procédés et des agents thérapeutiques pour abaisser ou élever les taux sériques de sérotonine chez un patient afin daugmenter ou diminuer la masse osseuse, respectivement. Dans des modes de réalisation préférés, on sait que le patient est atteint d'une maladie de la masse osseuse, ou présente un risque de contracter une maladie de la masse osseuse, telles que lostéoporose et les agents sont des inhibiteurs de TPH1 ou des antagonistes de récepteurs de sérotonine.
Ducy Patricia F.
Karsenty Gerard
Landry Donald
Xie Yuli
Yadav Vijay Kumar
Gowling Lafleur Henderson Llp
The Trustees Of Columbia University In The City Of New York
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