Methods of diagnosing, preventing and treating neurological...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2426658

The present invention identifies a gene whose gene product provides a protective effect against neurological disorders or neuronal injuries. Further, the invention provides methods for diagnosing or assessing an individual's susceptibility to a neuronal injury such as stroke. Also provided are therapeutic methods for treating patients, and methods for prophylactically treating individuals susceptible to various neurological disorders or neuronal injuries. Additionally, the invention describes screening methods for identifying agents that can be administered to treat individuals that have suffered or are at risk to suffer such disorders or injuries.

La présente invention permet d'identifier un gène dont le produit génique présente un effet protecteur contre des troubles neurologiques ou des lésions neuronales. En outre, l'invention concerne des procédés visant à diagnostiquer et à évaluer la prédisposition d'un individu à présenter à une lésion neuronale, telle qu'un accident vasculaire cérébral. L'invention concerne également des procédés thérapeutiques visant à traiter des patients et des procédés de traitement prophylactique des individus prédisposés à divers troubles neurologiques ou lésions neuronales. En outre, l'invention concerne des procédés de criblage visant à identifier des agents pouvant être administrés pour traiter des individus ayant souffert de tels troubles ou lésions ou présentant le risque de souffrir de tels troubles ou lésions.

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