C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C40B 30/00 (2006.01) G01N 33/483 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2725599
A method of determining the acute allograft rejection status of a subject, the method comprising the steps of deter-mining the nucleic acid expression profile of one or more than one nucleic acid markers, or one or more than one proteomic mark-ers in a biological sample from the subject, comparing the expression profile of the one or more than one nucleic acid markers to a control profile, and determining whether the expression level of the one or more than one nucleic acid markers is increased rela-tive to the control profile, wherein the increase of the one or more than one nucleic acid markers is indicative of the acute rejection status of the subject
L'invention porte sur un procédé de détermination de l'état de rejet d'allogreffe aigu d'un sujet. Ce procédé consiste à : déterminer le profil d'expression d'acide nucléique d'un ou plusieurs marqueurs d'acide nucléique, ou d'un ou plusieurs marqueurs protéomiques dans un échantillon biologique provenant du sujet; comparer le profil d'expression du ou des marqueurs d'acide nucléique à un profil témoin; et déterminer si le taux d'expression du ou des marqueurs d'acide nucléique est ou non augmenté par rapport au profil témoin, l'augmentation du ou des marqueurs d'acide nucléique étant indicative de l'état de rejet aigu du sujet.
Balshaw Robert
Cohen Freue Gabriela
Gunther Oliver
Keown Paul
Mcmanus Bruce
Fasken Martineau Dumoulin Llp
The University Of British Columbia
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