C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/25 (2006.01) G01N 33/68 (2006.01) G01N 33/92 (2006.01)
Patent
CA 2334892
A method is described to diagnose (1) renal salt wasting syndrome and (2) Alzheimer's disease among dementia patients by measuring a patient's level of prostaglandin D2 synthase. Methods are also described to (1) treat renal salt wasting syndrome, (2) inhibit the rate of apoptosis or (3) prevent the onset of, or slow the rate of, progression of Alzheimer's disease. These methods involve inhibiting the rate of -.DELTA.12prostaglandin J2 synthesis or by inhibiting the activity of -.DELTA.12prostaglandin J2.
L'invention concerne un procédé permettant de diagnostiquer (1) le syndrome rénal de perte de sel et (2) la maladie d'Alzheimer chez les patients atteints de démence, par mesure du niveau de prostaglandine D¿2? synthase chez ces patients. L'invention concerne également des procédés permettant de traiter (1) le syndrome rénal de perte de sel, (2) d'inhiber le taux d'apoptose, ou (3) d'empêcher l'apparition ou de ralentir la progression de la maladie d'Alzheimer. Ces procédés impliquent l'inhibition du taux de synthèse de -.DELTA.?12¿prostaglandine J¿2? ou l'inhibition de l'activité de la -.DELTA.?12¿prostaglandine J¿2?
Mccarthy Tetrault Llp
Winthrop-University Hospital
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