C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01)
Patent
CA 2183147
A novel association between inflamatory bowel disease (IBD) and a polymorphism at amino acid residue 241 or intracellular adhesion molecule-1 ICAM-1 has been discovered. In accordance with the present invention there is provided methods of screening for IBD, methods for treating IBD, antibodies specifically reactive with ICAM-1 encoded by R241 allele and kits which exploit the inventive methods.
Une nouvelle association ayant été découverte entre les affections inflammatoires intestinales et un polymorphisme au niveau du résidu d'acide aminé 241 de la molécule 1 d'adhésion endocellulaire (ICAM-1), la présente invention concerne plusieurs procédés permettant d'investiguer les affections inflammatoires intestinales, plusieurs procédés permettant de traiter les affections inflammatoires intestinales, des anticorps réagissant de façon spécifique à l'ICAM-1 codé par l'allèle R241, et des trousses de diagnostic utilisant les procédés de l'invention.
Beaudet Arthur L.
Rotter Jerome I.
Targan Stephan R.
Vora Devendra
Yang Huiying
Cedars-Sinai Medical Center
Osler Hoskin & Harcourt Llp
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