Methods of diagnosis and treatment for asthma, allergic...

A - Human Necessities – 61 – K

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A61K 31/553 (2006.01) A61K 39/395 (2006.01) A61P 11/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) C40B 30/00 (2006.01)

Patent

CA 2595875

Methods for diagnosis of asthma or allergic rhinitis or a susceptibility to asthma or allergic rhinitis based on detection of at-risk haplotypes associated with MAP3K9 are disclosed. Also methods for treatment of asthma or allergic rhinitis or a susceptibility to asthma or allergic rhinitis based on detection of at-risk haplotypes associated with MAP3K9 are disclosed. In particular, pathways targeting for treating individuals who are at-risk of developing asmtha or allergic rhinitis are described. In certain aspects, MLKl inhibitors are used in treatment methods.

La présente invention se rapporte à des méthodes de diagnostic de l'asthme, de la rhinite allergique ou d'une susceptibilité à l'asthme ou à la rhinite allergique, par détection d'haplotypes à risques associés à MAP3K9. L'invention se rapporte également à des méthodes de traitement de l'asthme, de la rhinite allergique ou d'une susceptibilité à l'asthme ou à la rhinite allergique, qui sont basées sur la détection d'haplotypes à risques associés à MAP3K9. En particulier, l'invention se rapporte au ciblage de voies permettant de traiter des sujets qui sont à risque s'agissant du développement d'un asthme ou d'une rhinite allergique. Dans certains aspects de l'invention, des inhibiteurs MLK1 sont utilisés dans des méthodes de traitement.

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