Methods of diagnosis and treatment of interstitial lung disease

Details Methods of diagnosis and treatment of interstitial lung disease Methods of diagnosis and treatment of interstitial lung disease

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61P 11/00 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2507613

The present invention provides for a method of treating pulmonary disease in a subject comprising the administration to a subject in need of such treatment a therapeutically effective amount of a formulation comprising a SP-C therapeutic. Preferably, the SP-C therapeutic is an agent selected from the group consisting of an isolated SP-C protein, an isolated nucleic acid molecule encoding a SP-C protein, a SP-C receptor-specific antibody that stimulates the activity of the receptor, or pharmaceutically acceptable composition thereof. The present invention also provides methods of producing a mouse with a targeted disruption in a surfactant protein C (SP-C) gene. The present invention also provides for a transgenic mouse produced by a targeted disruption in a surfactant protein C (SP-C) gene. The present invention further provides for a cell or cell line from a transgenic mouse produced by a targeted disruption in a surfactant protein C (SP-C) gene.

L'invention concerne un procédé de traitement d'une maladie pulmonaire chez un sujet. Ce procédé consiste à administrer à un sujet nécessitant un tel traitement une quantité efficace sur le plan thérapeutique d'une formulation contenant une protéine thérapeutique SP-C. De préférence, cette protéine thérapeutique SP-C consiste en un agent choisi dans le groupe constitué d'une protéine SP-C isolée, d'une molécule d'acide nucléique isolée codant une protéine SP-C, d'un anticorps spécifique au récepteur SP-C stimulant l'activité du récepteur ou d'une composition de celui-ci acceptable sur le plan pharmaceutique. Cette invention concerne également des procédés de production d'une souris à dissociation ciblée dans un gène de la protéine C du surfactant (SP-C). Cette invention concerne enfin une cellule ou une ligne cellulaire provenant d'une souris transgénique produite par dissociation ciblée dans un gène de la protéine C du surfactant (SP-C).

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