C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/35 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) A61K 39/04 (2006.01) A61P 31/06 (2006.01) C07H 21/04 (2006.01) C07K 7/08 (2006.01) C07K 16/12 (2006.01) G01N 33/53 (2006.01) G01N 33/563 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2577597
The present invention provides diagnostic, prognostic and therapeutic reagents for infection of an animal subject such as a human by M. tuberculosis, and conditions associated with such infections, such as, for example, tuberculosis. More particularly, the present invention provides a recombinant protein of M. tuberculosis designated "BSX" (SEQ ID NO: 1) and immunogenic epitopes thereof such as, for example, comprising SEQ ID NOS: 34, 25 and 45, that are useful in antibody-based diagnostic applications. The present invention also provides antibodies against BSX and its immunogenic peptides that are useful for antigen-based diagnostic and prognostic tests, and for therapy and vaccine formulations.
La présente invention concerne des réactifs de diagnostic, de pronostic et de traitement thérapeutique destinés à l~infection d~un sujet animal tel qu~un être humain par M. tuberculosis, et les pathologies associées à de telles infections, telles que par exemple, la tuberculose. Plus particulièrement, la présente invention concerne une protéine recombinante de M. tuberculosis, appelée « BSX » (SEQ ID NO: 1), et des épitopes immunogènes de celle-ci tels que, par exemple, SEQ ID NO: 34, 25 et 45, qui sont utiles pour des applications de diagnostic à base d~anticorps. La présente invention concerne également des anticorps anti-BSX et ses peptides immunogènes qui sont utiles pour les tests de diagnostic et de pronostic à base d~antigènes, et pour la thérapie et les formulations vaccinales.
Cole Robert Alan
Mackintosh James A.
Proteome Systems Intellectual Property Pty Ltd.
Proteome Systems Ltd.
Smart & Biggar
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