Methods of dosing propofol prodrugs for inducing mild to...

A - Human Necessities – 61 – K

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A61K 31/661 (2006.01) A61P 23/00 (2006.01)

Patent

CA 2614185

A dosage of a propofol prodrug needed for inducing mild to moderate sedation levels in a patient is calculated based on a patient's lean body mass. It has been discovered dosages based on gross body mass may result in overdosing, particularly for obese patients. In another aspect, a dosage suitable for inducing mild to moderate sedation levels in a patient who is at least 60 years of age is determined. A weight- appropriate dosage for the patient is determined and then adjusted by an age-based factor. For example, the dosage needed to produce a sedated state or other effect in a patient who is 60 years of age or older may be about 0.6 - 0.8 times the dosage needed to produce a corresponding effect in a younger patient of the same weight.

La présente invention concerne le dosage d~un promédicament de propofol nécessaire pour induire des niveaux de sédation légers à modérés chez un patient et qui est calculé sur une base du poids maigre d~un patient. On a découvert que les dosages calculés selon la masse corporelle brute peuvent entraîner un surdosage, en particulier chez les patients obèses. Un autre aspect de l~invention porte sur un dosage permettant d~induire des niveaux de sédation légers à modérés chez un patient d~au moins 60 ans. Un dosage adapté au poids du patient est alors déterminé et ensuite ajusté en tenant compte d~un facteur basé sur l~âge. Par exemple, le dosage nécessaire pour produire un état de sédation ou un autre effet chez un patient de 60 ans ou plus peut être de 0,6 à 0,8 fois le dosage nécessaire pour induire le même état chez un patient plus jeune et de même poids.

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