Methods of downmodulating the immune response to therapeutic...

A - Human Necessities – 61 – K

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A61K 38/37 (2006.01) A61K 38/17 (2006.01) A61K 38/48 (2006.01) A61K 39/395 (2006.01) A61P 7/04 (2006.01)

Patent

CA 2343916

Compositions and methods for treating a hemostatic disorder using agents which promote hemostasis and agents which inhibit a costimulatory signal in a T cell are provided. The instant compositions and methods enable the treatment of hemostatic disorders using foreign therapeutic proteins, while downmodulating immune responses to the therapeutic proteins.

L'invention concerne des compositions et des méthodes permettant de traiter des troubles hémostatiques au moyen d'agents stimulant l'hémostase et d'agents inhibant un signal costimulant dans un lymphocyte T. Les compositions et méthodes selon l'invention permettent de traiter les troubles hémostatiques au moyen de protéines thérapeutiques étrangères, tout en exerçant une modulation restrictive des réponses immunitaires à ces protéines thérapeutiques.

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