Methods of dry powder inhalation

Details Methods of dry powder inhalation Methods of dry powder inhalation

A - Human Necessities

61

M

A61M 15/00 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61K 38/02 (2006.01) A61K 38/22 (2006.01)

Patent

CA 2252814

A method for inhalation of a dry powder drug includes the steps of providing a dry powder drug composition having a drug particle size of from about 1-7 microns and a mass median aerodynamic diameter of the delivered aerosol of from about 3.5 to 5.5 microns. This composition is loaded into an inhaler which is generally flow rate independent, and with the inhaler having an inspiration flow resistance of about .12 to .21 (cmH2O)1/2 over the range of about 15-60 L/min. The patient inhales the drug composition from the inhaler with an inspiration flow rate of about 15-60 L/min, resulting in a delivery efficiency measured by respirable fraction greater than 20 %.

Méthode d'inhalation de médicaments sous forme de poudre sèche, qui consiste à produire une composition médicamenteuse en poudre sèche dont la taille des particules est d'environ 1 à 7 microns, le diamètre aérodynamique moyen en masse de l'aérosol administré étant d'environ 3,5 à 5,5 microns. La composition est chargée dans un inhalateur, qui est, en règle générale, indépendant du débit et qui possède une résistance au débit d'aspiration d'environ 0,12 à 0,21 (cmH¿2?O)?1/2¿ pour une plage comprise entre 15 et 60 L/min. Le patient inhale la composition médicamenteuse que contient l'inhalateur avec un débit d'aspiration qui varie entre 15 et 60 L/min, ce qui permet d'assurer une efficacité d'administration, mesurée en termes de fraction inhalable, dépassant les 20 %.

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