Methods of employing vascular leakage to diagnose a...

G - Physics – 01 – N

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G01N 33/92 (2006.01) A61B 5/1455 (2006.01)

Patent

CA 2689307

A method of diagnosing a capillary leak disorder in a patient includes monitoring the marinobufagenin level in blood and/or urine as indicators of vascular permeability and, if a substantial elevation in marinobufagenin exists with respect to that of a normal person, concluding that a capillary leak disorder exists. The method may be employed to diagnose preeclampsia, as well as illnesses or abnormal conditions selected from the group consisting of acute respiratory distress syndrome, hemorrhagic shock, septic, endotoxemia, septicemia, burns.

L'invention concerne un procédé de diagnostic d'un trouble de fuite capillaire chez un patient qui inclut les étapes consistant à : suivre le taux de marinobufagénine dans le sang et/ou l'urine comme indicateurs de la perméabilité vasculaire et, si une hausse substantielle de la marinobufagénine se présente par rapport à celle d'une personne normale, conclure qu'un trouble de fuite capillaire existe. Le procédé peut être employé pour diagnostiquer une prééclampsie, et également des maladies ou des états anormaux choisis dans le groupe constitué par le syndrome de détresse respiratoire aiguë, un choc hémorragique, un syndrome septique, une endotoxémie, une septicémie, des brûlures.

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