A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 9/00 (2006.01) A61P 37/04 (2006.01)
Patent
CA 2668649
Disclosed are methods of enhancing immune responses. Such methods involve the administration of vaccine compositions to different tissues to elicit an enhanced immune response. The enhanced response arises from the vaccination and boosting route of administration in two separate patient tissues, for example, by first administering a priming vaccination into skin and later administering a boost vaccination in muscle. In each case, priming and boosting, the administration of the vaccine composition is preferably carried out using contemporaneous electroporation-assisted delivery of the antigenic agent.
L'invention porte sur des méthodes renforçant la réponse immunitaire consistant: à administrer des compositions de vaccins à différents tissus pour susciter une réponse immunitaire accrue due non seulement à la vaccination mais également au doublement des voies d'administration soit dans deux tissus distincts du patient, par exemple d'abord une vaccination d'amorçage dans la peau, puis une vaccination de renfort dans le muscle. Dans chaque cas l'administration du vaccin se fait de préférence par délivrance assistée par électroporation de l'agent antigène.
Kjeken Rune
Lin Feng
Mathiesen Iacob
Rabussay Dietmar Paul
Tjelle Torunn Elisabeth
Genetronics Inc.
Smart & Biggar
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