A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01)
Patent
CA 2406654
The present invention provides novel and surprisingly effective methods for delivering nucleic acids to cells. These methods are based upon the discovery that the presence of endosomal membrane destabilizers (e.g., calcium) leads to a dramatic increase in the transfection efficiency of plasmids formulated as SPLP, or "stabilized plasmid-lipid particles."
La présente invention concerne des procédés nouveaux d'une efficacité surprenante permettant de délivrer des acides nucléiques à des cellules. Les procédés de l'invention reposent sur la découverte que la présence d'éléments déstabilisateurs de la membrane endosomale (par exemple, le calcium) entraîne une augmentation spectaculaire de l'efficacité de la transfection de plasmides formulés sous la forme de SPLP ou <= particules plasmides-lipides stabilisées >=.
Cullis Pieter R.
Lam Angela M. I.
Palmer Lorne R.
Fetherstonhaugh & Co.
The University Of British Columbia
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