G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/53 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2558670
Disclosed are methods for evaluating efficacy of an immune response by assessing alpha-l integrin, screening for, and manufacturing those therapeutic agents. Described herein the presence of VLA-1+ (positive) T cells indicates an effective immune response. Also disclosed are methods of screening for antigens that induce the production of VLA-1+ (positive) T cells, methods of isolating the antigens, and methods using the antigens identified in the screening methods to treat a subject with a disease.
L'invention concerne des procédés permettant d'évaluer l'efficacité d'une réponse immunitaire par l'évaluation de l'expression de l'intégrine alpha-1, des procédés de criblage associés, ainsi que des procédés de fabrication de ces agents thérapeutiques. Selon l'invention, la présence de lymphocytes T VLA-1+ (positifs) est le signe d'une réponse immunitaire efficace. L'invention concerne également des procédés de criblage d'antigènes induisant la production de lymphocytes T VLA-1+ (positifs), des procédés destinés à isoler lesdits antigènes, ainsi que des méthodes d'utilisation des antigènes identifiés par les procédés de criblage, dans le traitement de patients atteints de maladies.
Ray Steven J.
Topham David J.
Gowling Lafleur Henderson Llp
University Of Rochester
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