Methods of evaluating transplant rejection

Details Methods of evaluating transplant rejection Methods of evaluating transplant rejection

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2304159

The invention relates to methods of evaluating transplant rejection in a host comprising determining a heightened magnitude of gene expression of two out of three immune activation marker genes perforin, granzyme B and Fas ligand, in a tissue biopsy or peripheral blood mononuclear cell sample, particularly using reverse transcription polymerase chain reaction; methods of assessing antirejection therapy; and kits for use in evaluating transplant rejection.

La présente invention concerne des procédés permettant d'évaluer le rejet de greffes chez un hôte, lesquels procédés consistent à déterminer, en particulier au moyen de l'amplification en chaîne par polymérase à transcription inverse, l'amplitude accrue de l'expression génique de deux gènes marqueurs d'activation immunitaire sur trois: perforine, granzyme B et ligand Fas, dans une biopsie de tissu ou dans un prélèvement de cellules mononucléaires circulantes. La présente invention concerne également des procédés permettant d'évaluer la thérapie anti-rejet et des trousses destinées à évaluer le rejet des greffes.

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