Methods of expanding and selecting disease associated t-cells

Details Methods of expanding and selecting disease associated t-cells Methods of expanding and selecting disease associated t-cells

C - Chemistry, Metallurgy

12

N

C12N 5/0783 (2010.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01) A61P 37/02 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2335516

Methods of expanding and selecting disease associated T-cells, continuous T- cell lines as well as T-cell lines obtainable by these methods are disclosed. Furthermore, pharmaceutical compositions and vaccines comprising activated disease associated T-cell are disclosed. The uses of the T-cell and T-cell lines are numerous and include methods of diagnosis, methods for the treatment, alleviation or prevention of diseases associated with activation of T-cells, methods of testing the effect of medicaments against T-cell associated diseases, methods of detecting T-cell growth factors, methods of monitoring the response to treatment, alleviation or prevention of diseases associated with activation of T-cells, and methods of identifying disease associated antigens.

L'invention porte sur des méthodes de développement et de sélection des lymphocytes T associés à une pathologie de lignées continues de lymphocytes T, ainsi que sur les lignées de lymphocytes T pouvant être obtenues par ces procédés. L'invention porte également sur des compositions pharmaceutiques et des vaccins comprenant des lymphocytes T activés, associées à une pathologie. Les utilisations des lymphocytes T et des lignées de lymphocytes T sont nombreuses et comprennent des méthodes de diagnostic, de traitement, de soulagement ou de prévention de pathologies associées à l'activation des lymphocytes T, des méthodes visant à tester les effets des médicaments permettant de lutter contre des pathologies associées aux lymphocytes T, des méthodes de détection des facteurs de croissance des lymphocytes T, des méthodes visant à surveiller les réactions au traitement, le soulagement ou la prévention des pathologies associées à l'activation des lymphocytes T, et des méthodes d'identification d'antigènes associés à des pathologies.

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