Methods of fabricating enhanced tissue-engineered cartilage

C - Chemistry – Metallurgy – 12 – N

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C12N 5/077 (2010.01) A61L 27/36 (2006.01) A61F 2/30 (2006.01)

Patent

CA 2718174

Compositions and methods for fabricating a tissue-engineered cartilage construct comprising: providing a cell sample comprising a plurality of chondrocytes; culturing the cell sample to produce a tissue-engineered cartilage construct; and treating the tissue-engineered cartilage construct, wherein treating the tissue- engineered cartilage construct comprises the use of a biochemical reagent, a mechanical force, hydrostatic pressure, or any combination thereof.

L'invention porte sur des compositions et des procédés de fabrication d'un produit de construction de cartilage d'ingénierie tissulaire comprenant les opérations consistant : à se procurer un échantillon de cellule comprenant une pluralité de chondrocytes; à cultiver l'échantillon cellulaire pour obtenir un produit de construction de cartilage d'ingénierie tissulaire; et à traiter le produit de construction de cartilage d'ingénierie tissulaire, le traitement du produit de construction de cartilage d'ingénierie tissulaire comprenant l'utilisation d'un réactif biochimique, d'une force mécanique, d'une pression hydrostatique ou de toute combinaison de ceux-ci.

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