C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/071 (2010.01) A01N 1/02 (2006.01) A61K 35/12 (2006.01) A61L 27/38 (2006.01) C12M 3/00 (2006.01)
Patent
CA 2685964
The present invention describes processes and methods of fabricating and vascularising thick, three-dimensional, tissue constructs by preparing the constructs or portions thereof for freezing or vitrification with cryoprotectant solutions and/or including one or more cryoprotectant solutions as manufacturing materials in computer aided design, manufacturing, assembly and printing systems, (also known as bio- printing or organ-printing systems) and dispensing the prepared cells (or prepared self assembling cell aggregates) into a desired shape along with other desired materials and vitrifying or freezing the tissue construct which can be stored in a vitrified or frozen state by transporting the construct into a holding vessel (such as a vat) where more constructs of a similar nature can be added to the vat and may in some instances create a larger more elaborate structure such as a human organ which can than be removed from a vitrified or frozen state by warming the vat or transferring the construct to a holding vessel which will be equipped for allowing cellular adhesion to occur between the different constructs and self assembling tissue spheroids that have not yet had a chance to assembly due to their frozen or vitrified states. Also discussed are a variety of means for perfusing or vascularizing the construct comprising attaching the construct to a naturally existing or fabricated circulatory system comprising systems and methods of perfusing and circulating blood, nutrients, growth factors and other required materials through the construct.
Gillis Archie
Na
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