Methods of generating pluripotent cells from somatic cells

Details Methods of generating pluripotent cells from somatic cells Methods of generating pluripotent cells from somatic cells

C - Chemistry, Metallurgy

12

Q

C12Q 1/04 (2006.01) C12N 5/071 (2010.01) C12N 5/074 (2010.01) C12Q 1/68 (2006.01)

Patent

CA 2688539

Disclosed herein are methods to select for the generation of mouse and human pluripotent stem cells during developmental reprogramming. The methods described herein relate to the selection of induced pluripotent stem cells, i.e., pluripotent stem cells generated or induced from differentiated cells without a requirement for genetic selection. Described herein are particular embodiments for selection of reprogrammed cells based on 1) colony morphology, or 2) X chromosome reactivation in female cells.

L'invention concerne des procédés pour effectuer une sélection pour la génération de cellules souches pluripotentes de souris et humaines pendant une reprogrammation de développement. Les procédés décrits ici concernent la sélection de cellules souches pluripotentes induites, à savoir des cellules souches pluripotentes générées ou induites à partir de cellules différenciées sans exigence de sélection génétique. Des modes de réalisation particuliers sont décrits ici pour la sélection de cellules reprogrammées sur la base de 1) la morphologie des colonies, ou 2) la réactivation du chromosome X dans des cellules femelles.

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