Methods of identification, assessment, prevention and...

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G01N 33/48 (2006.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) C40B 40/10 (2006.01)

Patent

CA 2755301

The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. The invention also provides methods of differentiating lung disease, methods of monitoring therapy, and methods of predicting a subjects response to therapeutic intervention based on the extent of expression of the biomarkers and combinations of biomarkers. Kits comprising agents for detecting the biomarkers and combination of biomarkers are also provided.

L'invention porte sur des biomarqueurs et des combinaisons de biomarqueurs utiles dans le diagnostic de maladies pulmonaires, telles qu'un cancer des poumons non à petites cellules ou une affection respiratoire réactionnelle. L'invention porte également sur des procédés de différenciation de maladies pulmonaires, sur des procédés de surveillance de thérapie et sur des procédés de prédiction d'une réponse de sujets à une intervention thérapeutique sur la base de l'étendue de l'expression des biomarqueurs et des combinaisons de biomarqueurs. L'invention porte également sur des kits comprenant des agents pour détecter les biomarqueurs et une combinaison de biomarqueurs.

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