Methods of identifying activators of lyn kinase

Details Methods of identifying activators of lyn kinase Methods of identifying activators of lyn kinase

A - Human Necessities

61

K

A61K 31/505 (2006.01) A61K 31/155 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2678813

The present invention relates to methods of identifying activators of lyn kinase by preincubating a test compound in the presence of lyn kinase; adding ATP and substrate to the lyn kinase and test compound; incubating the test compound, lyn kinase, ATP, and substrate; and measuring phosphorylation level of the substrate, whereby an increase in the phosphorylation of the substrate indicates that the test compound is an activator of lyn kinase.

La présente invention se rapporte à des procédés d'identification d'activateurs de LYN kinase comprenant les étapes suivantes : pré-incubation d'un mélange de test en présence de LYN kinase; ajout d'ATP et d'un substrat à la LYN kinase et au mélange de test; incubation du mélange de test, de la LYN kinase, de l'ATP et du substrat; et mesure du niveau de phosphorylation du substrat - une augmentation du niveau de phosphorylation du substrat indiquant que le mélange de test est un activateur de LYN kinase.

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