C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) C12N 1/00 (2006.01) C12N 15/65 (2006.01) C12N 15/79 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) C07K 14/775 (2006.01) C07K 19/00 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2631706
The present invention provides isolated cells comprising a nucleic acid encoding a toxic form of apoE. The present invention further provides screening methods for identifying compounds that reduce apoE-induced impairment of mitochondrial integrity and/or function. The present invention further provides kits for use in carrying out a subject screening method. The present invention provides agents that reduce apoE-induced impairment of mitochondrial integrity and/or function; and use of such agents in the treatment of apoE-related disorders.
La présente invention concerne des cellules isolées contenant un acide nucléique codant pour une forme toxique de la protéine apoE. La présente invention concerne des procédés de criblage permettant d'identifier des composés qui réduisent l'altération de l'intégrité et/ou du fonctionnement mitochondrial(e) due à la protéine apoE. La présente invention concerne également des trousses permettant de procéder à un dépistage sur un patient. La présente invention concerne des agents qui réduisent l'altération de l'intégrité et/ou du fonctionnement mitochondrial(e) due à la protéine apoE; et l'utilisation de ces agents pour traiter des troubles liés à la protéine apoE.
Brodbeck Jens
Huang Yadong
Fetherstonhaugh & Co.
The J. David Gladstone Institutes
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