Methods of identifying antagonists of...

Details Methods of identifying antagonists of... Methods of identifying antagonists of...

G - Physics

01

N

G01N 33/53 (2006.01) C07C 311/45 (2006.01) C07D 209/42 (2006.01) C07D 307/54 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2236827

Disclosed is a method of identifying agents (or aiding in the selection of agents or a method of screening for agents) which inhibit the binding of heparin or analogs of heparin with proteins whose activity is modulated with glycosaminoglycans. In this method, the compounds of a combinatorial library comprising compounds having a molecular weight between about 500 amu and about 1500 amu, or a subset of the compounds in the combinatorial library, are screened in an assay for detecting inhibition of binding between glycosaminoglycans and a protein which is activated by a glycosaminoglycan. Compounds which show activity in the assay are selected for further, more advanced testing.

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