Methods of identifying compounds that modulate protein activity

Details Methods of identifying compounds that modulate protein activity Methods of identifying compounds that modulate protein activity

C - Chemistry, Metallurgy

12

N

C12N 15/61 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/40 (2006.01) C12N 9/00 (2006.01) C12N 9/10 (2006.01) C12N 9/88 (2006.01) C12N 9/90 (2006.01) C12N 15/12 (2006.01) C12N 15/54 (2006.01) C12N 15/60 (2006.01) C12Q 1/00 (2006.01) C12Q 1/48 (2006.01) C12Q 1/527 (2006.01) C12Q 1/533 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2495123

Methods of identifying compounds that modulate target polypeptide activity, where a test compound is combined with a target polypeptide and a substrate of the target polypeptide and where a determination is made as to whether the test compound modulates activity of the target polypeptide. The test compounds could be small molecule drugs used for treatment of obestiy, diabetes, insulin resistance, and for enhancement of insulin secretion. Target polypeptides and their corresponding nucleic acids as well as their variants are also disclosed.

La présente invention concerne des procédés pour identifier des composés qui modulent l'activité de polypeptides cibles. Ce procédé consiste à combiner un composé testé à un polypeptide cible et à un substrat du polypeptide cible, puis à déterminer si le composé testé module l'activité du polypeptide cible. Les composés testés peuvent être des médicaments à petites molécules, utilisés pour traiter une obésité, un diabète ou une résistance à l'insuline et pour améliorer la sécrétion d'insuline. La présente invention concerne également des polypeptides cibles et leurs acides nucléiques correspondants, ainsi que leurs variantes.

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