C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/395 (2006.01) C07K 14/47 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/554 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2197233
Disclosed are methods of identifying compounds which inhibit transcription activation by CIITA and thus inhibit MHC class II gene expression. Such compounds can affect the induction of an immune response. The methods employ, independently, the activation and interactions domains of CIITA. The methods also employ the activation and interaction domains of isotype-specific CIITA proteins, allowing for the identification of compounds which are isotype- specific inhibitors of transcription and which are useful for selectively affecting the immune system.
La présente invention concerne des procédés d'identification de composés empêchant l'activation de la transcription par le CIITA, et empêchant par conséquent l'expression du gène MHC de classe II. Ce type de composés peut affecter l'induction d'une réaction immunitaire. Ces procédés mettent en oeuvre indépendamment, les domaines d'activation et d'interactions du CIITA. Ces procédés mettent en oeuvre également les domaines d'activation et d'interaction de protéines spécifiques par isotype du CIITA, ce qui permet l'identification de composés qui sont des inhibiteurs de transcription spécifiques par isotype, et qui sont utiles pour intervenir de façon spécifique sur le système immunitaire.
Douhan John III
Glimcher Laurie H.
Zhou Hong
Borden Ladner Gervais Llp
President And Fellows Of Harvard College
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