C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12Q 1/04 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2179281
This invention provides methods for identifying lymphocytes with a mutator phenotype by isolating lymphocytes bearing a selectable marker; identifying among the lymphocytes a population belonging to the same clonally amplified set; and determining whether the population has at least two lymphocytes having, between them, two independent mutations among different alleles at the gene locus of the selectable marker; the presence of which indicates a mutator phenotype. In one embodiment of the invention, the selectable marker is hprt-.
L'invention décrit des procédés permettant d'identifier des lymphocytes avec un phénotype mutateur, et consistant à isoler des lymphocytes portant un marqueur sélectionnable; à identifier parmi ces lymphocytes une population appartenant au même ensemble d'identification clonale; et à déterminer si cette population présente au moins deux lymphocytes ayant, entre eux, deux mutations indépendantes parmi différents allèles au niveau du locus génique du marqueur sélectionnable; la présence de ces lymphocytes indique un phénotype mutateur. Dans un mode de réalisation de l'invention, le marqueur sélectionnable est ihprt?-¿.
Smart & Biggar
University Of Vermont
LandOfFree
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