Methods of identifying modulators of kinases responsive to...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/48 (2006.01) A61K 31/663 (2006.01) A61K 45/00 (2006.01) A61K 45/06 (2006.01) A61P 19/00 (2006.01) A61P 19/10 (2006.01) C12N 9/12 (2006.01) C12Q 1/00 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2317459

The present invention relates to methods of identifying compounds useful as modulators of certain stress responsive kinases. More particularly, the compounds so identified are useful for treating or preventing diseases or conditions that are mediated by, for example, abnormal bone resorption or angiogenesis. These compounds are useful for treating or preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, and tumor growth.

L'invention concerne des procédés servant à identifier des composés utiles en tant que modulateurs de certaines kinases sensibles au stress. Plus particulièrement, les composés ainsi identifiés sont utiles pour traiter ou prévenir des maladies ou des états provoqués, par exemple, par une résorption osseuse anormale ou par l'angiogenèse. Ces composés sont utiles pour traiter ou prévenir l'ostéoporose et pour inhiber la resténose, la rétinopathie diabétique, la dégénérescence maculaire, l'angiogenèse, l'athérosclérose, l'inflammation et la croissance tumorale.

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