C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C07K 14/71 (2006.01) C30B 7/00 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2397135
The present invention provides fragments of SNT and FGFR which can form a binding complex that is amenable to structural determinations by NMR spectroscopy. The three-dimensional structural data is also included as part of the invention. In addition, the present invention provides methodology for related structure based rational drug design using the three-dimensional data. Nucleotide and amino acid sequences of the fragments are also provided.
L'invention concerne des fragments du SNT et du FGFR pouvant former un complexe de liaison qui se prête aux déterminations structurelles par spectroscopie RMN. L'invention concerne en outre les données structurelles tridimensionnelles correspondantes. L'invention concerne aussi une méthodologie applicable à la conception rationnelle structurelle connexe de médicaments reposant sur les données en question. L'invention concerne également des séquences nucléotidiques et des séquences d'acides aminés de ces fragments.
Mount Sinai School Of Medicine
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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