Methods of identifying modulators of ubiquitin ligases

Details Methods of identifying modulators of ubiquitin ligases Methods of identifying modulators of ubiquitin ligases

C - Chemistry, Metallurgy

12

Q

C12Q 1/25 (2006.01) C40B 30/04 (2006.01) G01N 33/573 (2006.01) C12N 9/00 (2006.01)

Patent

CA 2731704

Methods for identifying ubiquitin ligases and ubiquitin ligase modulators are disclosed. The methods comprise combining the components of a ubiquitylation reaction and using proteins that contain motifs that recognize ubiquitylated sites in the detection of ubiquitylation.

La présente invention a pour objet des procédés permettant lidentification dubiquitine ligases et de modulateurs dubiquitine ligases. Les procédés comprennent la combinaison des composants dune réaction dubiquitylation et lutilisation de protéines qui contiennent des motifs qui reconnaissent les sites ubiquitylés dans la détection de lubiquitylation.

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