Methods of identifying patients at risk of developing...

Details Methods of identifying patients at risk of developing... Methods of identifying patients at risk of developing...

G - Physics

01

N

G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2571856

The present invention generally relates to a method for an improved treatment for Alzheimer~s disease (AD) using immunotherapy, e.g., immunotherapy targeting .beta. amyloid (A.beta.), e.g. immunotherapy based on AN1792. In one embodiment, the method allows for predicting an adverse clinical response, and therefore allows for an improved safety profile of AN1792. In another embodiment, the method allows for predicting a favorable clinical response, and therefore allows for an improved efficacy profile of AN1792. The methods of the present invention may be combined to predict a favorable clinical response and the lack of an adverse clinical response.

D'une manière générale, la présente invention a trait à un traitement amélioré pour la maladie d'Alzheimer au moyen d'une immunothérapie, par exemple, une immunothérapie ciblant l'amyloïde .beta., une immunothérapie à base de AN1792. Dans un mode de réalisation, le procédé permet la prédiction d'une réaction clinique indésirable, et permet donc de fournir un profil de sécurité améliorée de AN1792. Dans un autre mode de réalisation, le procédé permet la prédiction d'une réaction favorable, et permet donc de fournir un profil d'efficacité améliorée de AN1792. Les procédés de la présente invention peuvent être combinés pour la prédiction d'une réaction clinique favorable et l'absence d'une réaction clinique indésirable.

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