Methods of identifying potentially therapeutically effective...

Details Methods of identifying potentially therapeutically effective... Methods of identifying potentially therapeutically effective...

C - Chemistry, Metallurgy

12

Q

C12Q 1/37 (2006.01) C12Q 1/02 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2161771

The present invention is to a method of screening agents for potential therapeutic efficacy. The method comprises exposing a cell strain that is sensitive to known apoptotic agents to said apoptotic agents and to a potential therapeutic agent. The cell strain is then cultured and cells are removed that display diminished adherence. The remaining, adherent, cells are then incubated in the presence of a proteinase to release proteinase sensitive cells. The proteinase sensitive cells are removed to yield proteinase resistant cells and the proteinase sensitive cells are counted. The proteinase resistant cells are then collected and counted. The agent is determined to have potential therapeutic efficacy if the ratio of proteinase sensitive cells to proteinase resistant cells changes relative to a control as a result of the presence of the agent.

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