Methods of identifying the activity of gene products

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01) C12N 15/10 (2006.01) G01N 33/53 (2006.01) G01N 33/554 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2408812

Methods are disclosed for determining the activity and function of gene products based on their change to the phenotype of cells when contacted with a surrogate molecule identified through screening of a recombinant peptide library. By identifying peptides which bind gene products for which the function is not yet known, tools are provided for determining their function and obtaining drug candidates.

La présente invention concerne des techniques permettant de déterminer l'activité et la fonction de produits géniques fondées sur la modification apportée au phénotype des cellules lorsque ces dernières sont mises en contact avec une molécule auxiliaire identifiée par criblage d'une bibliothèque de peptides de recombinaison. Par l'identification de peptides qui se lient aux produits géniques pour lesquels la fonction n'est pas encore connue, on obtient des outils permettant de déterminer leur fonction et d'obtenir des médicaments candidat.

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