Methods of immunosuppression

Details Methods of immunosuppression Methods of immunosuppression

C - Chemistry, Metallurgy

12

N

C12N 5/06 (2006.01) A61K 39/00 (2006.01) A61P 37/00 (2006.01) C12N 5/08 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2354147

A method for producing a T cell having tolerance to an allergen or antigen which method comprises incubating the T cell with an antigen presenting cell (APC) in the presence of (i) a composition capable of upregulating expression of an endogenous Notch ligand in the APC and (ii) the allergen or antigen is provided.

L'invention concerne un procédé de production d'un lymphocyte T tolérant à un allergène ou antigène, qui consiste à incuber le lymphocyte T avec une cellule présentatrice de l'antigène (CPA), en présence i) d'une composition capable de réguler positivement l'expression d'un ligand Notch endogène dans la CPA, et ii) de l'allergène ou antigène.

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