Methods of increasing amyloid deposition

Details Methods of increasing amyloid deposition Methods of increasing amyloid deposition

C - Chemistry, Metallurgy

07

H

C07H 15/04 (2006.01) A01K 67/027 (2006.01) A61K 31/00 (2006.01) A61K 31/185 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61P 25/28 (2006.01) C07C 305/06 (2006.01) C12Q 1/00 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2219447

In vivo and in vitro methods of increasing amyloid deposition using amyloid- enhancing compounds are described. Methods of forming amyloid fibrils and screening for agents useful in treating amyloidosis are also described. Animals having non-naturally occurring amyloid deposits produced using the amyloid-enhancing compounds even further are described.

L'invention, qui porte sur des procédés in vivo et in vitro permettant d'accroître le dépôt de plaques amyloïdes en faisant appel à des composés de stimulation amyloïde, concerne également des procédés de production de fibrilles amyloïdes et de criblage d'agents efficaces dans le traitement de l'amylose. L'invention concerne en outre des animaux présentant des dépôts de plaques amyloïdes non naturels, obtenus en faisant appel à des composés de stimulation amyloïde.

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