Methods of inducing bef-1 transcription factor

Details Methods of inducing bef-1 transcription factor Methods of inducing bef-1 transcription factor

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/4535 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2223175

A method of inducing BEF-1 transcription factor comprising administering to a human in need thereof an effective amount of a compound having formula (I), wherein R1 and R3 are independently hydrogen, -CH3, (a), or (b), wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamethyleneamino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.

L'invention concerne un procédé pour induire le facteur de transcription BEF-1 consistant à administrer à un patient une quantité suffisante pour avoir un effet, d'un composé de la formule (I). Dans cette formule, R?1¿ et R?3¿ sont d'une manière indépendante hydrogène, -CH¿3?, (a) ou (b), où Ar est un groupe phényle, le cas échéant substitué; R?2¿ est choisi dans le groupe constitué par: pyrrolidine, hexaméthylèneamino et pipéridino. L'invention concerne également les sels et les solvates de ces composés, acceptables sur le plan pharmaceutique.

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