A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/167 (2006.01) A61P 35/00 (2006.01) C07C 259/06 (2006.01)
Patent
CA 2671976
The present invention provides methods of selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by administration of pharmaceutical compositions comprising potent HDAC inhibitors. The oral bioavailability of the active compounds in the pharmaceutical compositions of the present invention is surprisingly high. Moreover, the pharmaceutical compositions unexpectedly give rise to high, therapeutically effective blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors in vivo.
Chiao Judy H.
Kelly W. Kevin
Miller Thomas A.
Richon Victoria M.
Merck Hdac Research Llc
Merck Hdac Research Llc.
Ridout & Maybee Llp
Sloan-Kettering Institute For Cancer Research
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